Small molecule approaches to treat autoimmune and inflammatory diseases (Part II): Nucleic acid sensing antagonists and inhibitors

Xiaoqing Wang; Yafei Liu; Xingchun Han; Ge Zou; Wei Zhu; Hong Shen; Haixia Liu

doi:10.1016/j.bmcl.2021.128101

Small molecule approaches to treat autoimmune and inflammatory diseases (Part II): Nucleic acid sensing antagonists and inhibitors

Bioorg Med Chem Lett. 2021 Jul 15:44:128101. doi: 10.1016/j.bmcl.2021.128101. Epub 2021 May 10.

Authors

Xiaoqing Wang¹, Yafei Liu¹, Xingchun Han¹, Ge Zou¹, Wei Zhu¹, Hong Shen¹, Haixia Liu²

Affiliations

¹ Department of Medicinal Chemistry, Roche Innovation Center Shanghai, Roche Pharma Research and Early Development, Shanghai 201203, China.
² Department of Medicinal Chemistry, Roche Innovation Center Shanghai, Roche Pharma Research and Early Development, Shanghai 201203, China. Electronic address: haixia.liu@roche.com.

PMID: 33984476
DOI: 10.1016/j.bmcl.2021.128101

Abstract

Nucleic acid sensing pathways play an important role in the innate immune system, protecting hosts against infections. However, a large body of evidence supports a close association between aberrant activation of those pathways and autoimmune and inflammatory diseases. Part II of the digest series on small molecule approaches to autoimmune and inflammatory diseases concentrates on recent advances with respect to small molecule antagonists or inhibitors of the nucleic acid sensing pathways, including endosomal TLRs, NLRP3 inflammasome and cGAS-STING.

Keywords: Autoimmune and inflammatory diseases; Inhibitors; Innate immunity; Nucleic acid; Small molecule antagonists.

Publication types

Review

MeSH terms

Animals
Autoimmune Diseases / drug therapy*
DNA / drug effects*
Dose-Response Relationship, Drug
Humans
Inflammation / drug therapy*
Molecular Structure
RNA / drug effects*
Small Molecule Libraries / chemistry
Small Molecule Libraries / pharmacology*
Structure-Activity Relationship

Substances

Small Molecule Libraries
RNA
DNA